Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart

TGF-βs regulate fibroblast responses, by activating Smad2 or Smad3 signaling, or via Smad independent pathways. We have previously demonstrated that myofibroblast-specific Smad3 is critically implicated in repair of the infarcted heart. However, the role of fibroblast Smad2 in myocardial infarction...

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Udgivet i:J Mol Cell Cardiol
Main Authors: Huang, Shuaibo, Chen, Bijun, Su, Ya, Alex, Linda, Humeres, Claudio, Shinde, Arti V, Conway, Simon J, Frangogiannis, Nikolaos G
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579679/
https://ncbi.nlm.nih.gov/pubmed/31085202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.05.006
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