Opposing actions of fibroblast and cardiomyocyte Smad3 signaling in the infarcted myocardium: Kong et al. Cell-specific actions of Smad3 in infarction

BACKGROUND: Transforming Growth Factor (TGF)-βs regulate a wide range of cellular responses by activating Smad-dependent and Smad-independent cascades. In the infarcted heart, Smad3 signaling is activated in both cardiomyocytes and interstitial cells. We hypothesized that cell-specific actions of Sm...

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Bibliografiske detaljer
Udgivet i:Circulation
Main Authors: Kong, Ping, Shinde, Arti V, Su, Ya, Russo, Ilaria, Chen, Bijun, Saxena, Amit, Conway, Simon J, Graff, Jonathan M, Frangogiannis, Nikolaos G
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812838/
https://ncbi.nlm.nih.gov/pubmed/29229611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.029622
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