Monocyte-derived CD11c(+) cells acquire Plasmodium from hepatocytes to prime CD8 T cell immunity to liver-stage malaria

Plasmodium sporozoites inoculated by mosquitoes migrate to the liver and infect hepatocytes prior to release of merozoites that initiate symptomatic blood-stage malaria. Plasmodium parasites are thought to be restricted to hepatocytes throughout this obligate liver-stage of development, and how live...

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Détails bibliographiques
Publié dans:Cell Host Microbe
Auteurs principaux: Kurup, Samarchith P., Anthony, Scott M., Hancox, Lisa S., Vijay, Rahul, Pewe, Lecia L., Moioffer, Steven J., Sompallae, Ramakrishna, Janse, Chris J., Khan, Shahid M., Harty, John T.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459714/
https://ncbi.nlm.nih.gov/pubmed/30905437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.02.014
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