Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

Cellular senescence is a driver of various aging-associated disorders, including osteoarthritis. Here, we identified a critical role for Yes-associated protein (YAP), a major effector of Hippo signaling, in maintaining a younger state of human mesenchymal stem cells (hMSCs) and ameliorating osteoart...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Biol
Prif Awduron: Fu, Lina, Hu, Yuqiong, Song, Moshi, Liu, Zunpeng, Zhang, Weiqi, Yu, Fa-Xing, Wu, Jun, Wang, Si, Izpisua Belmonte, Juan Carlos, Chan, Piu, Qu, Jing, Tang, Fuchou, Liu, Guang-Hui
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459557/
https://ncbi.nlm.nih.gov/pubmed/30933975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000201
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