Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features

The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis to investigate how VRC01 prevention efficacy (PE) varies with HIV-1 envelope (Env) amin...

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Publicado en:PLoS Comput Biol
Main Authors: Magaret, Craig A., Benkeser, David C., Williamson, Brian D., Borate, Bhavesh R., Carpp, Lindsay N., Georgiev, Ivelin S., Setliff, Ian, Dingens, Adam S., Simon, Noah, Carone, Marco, Simpkins, Christopher, Montefiori, David, Alter, Galit, Yu, Wen-Han, Juraska, Michal, Edlefsen, Paul T., Karuna, Shelly, Mgodi, Nyaradzo M., Edugupanti, Srilatha, Gilbert, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459550/
https://ncbi.nlm.nih.gov/pubmed/30933973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006952
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