Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features

The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis to investigate how VRC01 prevention efficacy (PE) varies with HIV-1 envelope (Env) amin...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: Magaret, Craig A., Benkeser, David C., Williamson, Brian D., Borate, Bhavesh R., Carpp, Lindsay N., Georgiev, Ivelin S., Setliff, Ian, Dingens, Adam S., Simon, Noah, Carone, Marco, Simpkins, Christopher, Montefiori, David, Alter, Galit, Yu, Wen-Han, Juraska, Michal, Edlefsen, Paul T., Karuna, Shelly, Mgodi, Nyaradzo M., Edugupanti, Srilatha, Gilbert, Peter B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459550/
https://ncbi.nlm.nih.gov/pubmed/30933973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006952
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