Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca(2+) Leak Directed to Mitochondria in Pancreatic Islets and β-Cells

BACKGROUND/AIMS: In pancreatic β-cells, the intracellular Ca(2+) homeostasis is an essential regulator of the cells’ major functions. The endoplasmic reticulum (ER) as interactive intracellular Ca(2+) store balances cellular Ca(2+). In this study basal ER Ca(2+) homeostasis was evaluated in order to...

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Vydáno v:Cell Physiol Biochem
Hlavní autoři: Klec, Christiane, Madreiter-Sokolowski, Corina T., Stryeck, Sarah, Sachdev, Vinay, Duta-Mare, Madalina, Gottschalk, Benjamin, Depaoli, Maria R., Rost, Rene, Hay, Jesse, Waldeck-Weiermair, Markus, Kratky, Dagmar, Madl, Tobias, Malli, Roland, Graier, Wolfgang F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459368/
https://ncbi.nlm.nih.gov/pubmed/30790505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.33594/000000005
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