PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells

Recent studies revealed that mitochondrial Ca(2+) channels, which control energy flow, cell signalling and death, are macromolecular complexes that basically consist of the pore-forming mitochondrial Ca(2+) uniporter (MCU) protein, the essential MCU regulator (EMRE), and the mitochondrial Ca(2+) upt...

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Publicat a:Nat Commun
Autors principals: Madreiter-Sokolowski, Corina T., Klec, Christiane, Parichatikanond, Warisara, Stryeck, Sarah, Gottschalk, Benjamin, Pulido, Sergio, Rost, Rene, Eroglu, Emrah, Hofmann, Nicole A., Bondarenko, Alexander I., Madl, Tobias, Waldeck-Weiermair, Markus, Malli, Roland, Graier, Wolfgang F.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031806/
https://ncbi.nlm.nih.gov/pubmed/27642082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12897
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