Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC

Although the role of urea in urine concentration is known, the effect of urea handling by the urea transporters (UTs), UT-A1 and UT-A3, on sodium balance remains elusive. Serum and urinary sodium concentration is similar between wild-type mice (WT) and UT-A3 null (UT-A3 KO) mice; however, mice lacki...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Rogers, Richard T., Sun, Michael A., Yue, Qiang, Bao, Hui-Fang, Sands, Jeff M., Blount, Mitsi A., Eaton, Douglas C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459308/
https://ncbi.nlm.nih.gov/pubmed/30539654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00166.2018
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