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Fructose acutely stimulates NKCC2 activity in rat thick ascending limbs by increasing surface NKCC2 expression

The thick ascending limb (TAL) reabsorbs 25% of the filtered NaCl through the Na(+)-K(+)-2Cl(−) cotransporter (NKCC2). NKCC2 activity is directly related to surface NKCC2 expression and phosphorylation. Higher NaCl reabsorption by TALs is linked to salt-sensitive hypertension, which is linked to con...

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Publicado en:Am J Physiol Renal Physiol
Autores principales: Ares, Gustavo R., Kassem, Kamal M., Ortiz, Pablo A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459307/
https://ncbi.nlm.nih.gov/pubmed/30516424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00136.2018
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