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Superoxide increases surface NKCC2 in the rat thick ascending limbs via PKC
The apical Na(+)-K(+)-2Cl(−) cotransporter (NKCC2) mediates NaCl reabsorption by the thick ascending limb (TAL). The free radical superoxide ([Formula: see text]) stimulates TAL NaCl absorption by enhancing NKCC2 activity. In contrast, nitric oxide (NO) scavenges [Formula: see text] and inhibits NKC...
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| Publicado no: | Am J Physiol Renal Physiol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7139495/ https://ncbi.nlm.nih.gov/pubmed/31091128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00232.2018 |
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