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Superoxide increases surface NKCC2 in the rat thick ascending limbs via PKC

The apical Na(+)-K(+)-2Cl(−) cotransporter (NKCC2) mediates NaCl reabsorption by the thick ascending limb (TAL). The free radical superoxide ([Formula: see text]) stimulates TAL NaCl absorption by enhancing NKCC2 activity. In contrast, nitric oxide (NO) scavenges [Formula: see text] and inhibits NKC...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Haque, Mohammed Ziaul, Ortiz, Pablo A.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139495/
https://ncbi.nlm.nih.gov/pubmed/31091128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00232.2018
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