Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates

Antibody-drug conjugates (ADCs) convey highly potent anticancer drugs to antigen-expressing tumor cells, thereby sparing healthy tissues throughout the body. Pharmacokinetics and tolerability of ADCs are predominantly influenced by the drug-antibody ratio (DAR) of the conjugates, which is to-date li...

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Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Viricel, Warren, Fournet, Guy, Beaumel, Sabine, Perrial, Emeline, Papot, Sébastien, Dumontet, Charles, Joseph, Benoît
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2019
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457330/
https://ncbi.nlm.nih.gov/pubmed/31015945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc00285e
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