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Resurrecting the bacterial tyrosyl-tRNA synthetase/tRNA pair for expanding the genetic code of both E. coli and eukaryotes

The bacteria-derived tyrosyl-tRNA synthetase (TyrRS)/tRNA pair was first used for unnatural amino acid (Uaa) mutagenesis in eukaryotic cells over 15 years ago. It provides an ideal platform to genetically encode numerous useful Uaas in eukaryotes. However, this pair has been engineered to charge onl...

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Dettagli Bibliografici
Pubblicato in:Cell Chem Biol
Autori principali: Italia, James S., Latour, Christopher, Wrobel, Chester J. J., Chatterjee, Abhishek
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456809/
https://ncbi.nlm.nih.gov/pubmed/30078635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.07.002
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