Antithrombotic Effect of shRNA Target F12 Mediated by Adeno-Associated Virus

Coagulation factor XII (FXII) plays a crucial role in thrombosis. Moreover, deficiencies in FXII are not associated with excessive bleeding, and its depletion exhibits satisfactory protective effect on thrombus formation. Several strategies targeting FXII have been applied to inhibit thrombosis form...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Li, Fanfan, Yang, Xiao, Liu, Jie, Shu, Kuangyi, Shen, Chenfang, Chen, Tao, Yang, Wei, Li, Shanshan, Wang, Xiaoou, Jiang, Minghua
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454094/
https://ncbi.nlm.nih.gov/pubmed/30959404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.02.026
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