Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release

Processing of pro-interleukin (IL)-1β and IL-18 is regulated by multiprotein complexes, known as inflammasomes. Inflammasome activation results in generation of bioactive IL-1β and IL-18, which can exert potent pro-inflammatory effects. Our aim was to develop a whole blood-based assay to study the i...

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Udgivet i:PLoS One
Main Authors: Tran, Thi Anh Thu, Grievink, Hendrika W., Lipinska, Katarzyna, Kluft, Cornelis, Burggraaf, Jacobus, Moerland, Matthijs, Tasev, Dimitar, Malone, Karen E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453527/
https://ncbi.nlm.nih.gov/pubmed/30958862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0214999
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