Age-related inflammation triggers skeletal stem/progenitor cell dysfunction

Aging is associated with impaired tissue regeneration. Stem cell number and function have been identified as potential culprits. We first demonstrate a direct correlation between stem cell number and time to bone fracture union in a human patient cohort. We then devised an animal model recapitulatin...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Josephson, Anne Marie, Bradaschia-Correa, Vivian, Lee, Sooyeon, Leclerc, Kevin, Patel, Karan S., Muinos Lopez, Emma, Litwa, Hannah P., Neibart, Shane S., Kadiyala, Manasa, Wong, Madeleine Z., Mizrahi, Matthew M., Yim, Nury L., Ramme, Austin J., Egol, Kenneth A., Leucht, Philipp
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452701/
https://ncbi.nlm.nih.gov/pubmed/30894483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810692116
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