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Age-related inflammation triggers skeletal stem/progenitor cell dysfunction

Aging is associated with impaired tissue regeneration. Stem cell number and function have been identified as potential culprits. We first demonstrate a direct correlation between stem cell number and time to bone fracture union in a human patient cohort. We then devised an animal model recapitulatin...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Josephson, Anne Marie, Bradaschia-Correa, Vivian, Lee, Sooyeon, Leclerc, Kevin, Patel, Karan S., Muinos Lopez, Emma, Litwa, Hannah P., Neibart, Shane S., Kadiyala, Manasa, Wong, Madeleine Z., Mizrahi, Matthew M., Yim, Nury L., Ramme, Austin J., Egol, Kenneth A., Leucht, Philipp
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452701/
https://ncbi.nlm.nih.gov/pubmed/30894483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810692116
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