FLUOXETINE INHIBITS OSTEOBLAST DIFFERENTIATION & MINERALIZATION IN FRACTURE HEALING: The Selective Serotonin Reuptake Inhibitor Fluoxetine Directly Inhibits Osteoblast Differentiation and Mineralization During Fracture Healing in Mice

Chronic use of selective serotonin reuptake inhibitors (SSRIs) for the treatment of depression has been linked to osteoporosis. In this study, we investigated the effect of chronic SSRI use on fracture healing in two murine models of bone regeneration. First, we performed a comprehensive analysis of...

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Veröffentlicht in:J Bone Miner Res
Hauptverfasser: Bradaschia-Correa, Vivian, Josephson, Anne M, Mehta, Devan, Mizrahi, Matthew, Neibart, Shane S, Liu, Chao, Kennedy, Oran, Castillo, Alesha B, Egol, Kenneth A, Leucht, Philipp
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395314/
https://ncbi.nlm.nih.gov/pubmed/27869327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3045
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