Temporary inhibition of the plasminogen activator inhibits periosteal chondrogenesis and promotes periosteal osteogenesis during appendicular bone fracture healing

INTRODUCTION: Aminocaproic acid is approved as an anti-fibrinolytic for use in joint replacement and spinal fusion surgeries to limit perioperative blood loss. Previous animal studies have demonstrated a pro-osteogenic effect of aminocaproic acid in spine fusion models. Here, we tested if aminocapro...

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Detalhes bibliográficos
Publicado no:Bone
Main Authors: Bravo, D, Josephson, AM, Bradaschia-Correa, V, Wong, M, Yim, N, Neibart, SS, Lee, SN, Huo, J, Coughlin, T, Mizrahi, M, Leucht, P
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970081/
https://ncbi.nlm.nih.gov/pubmed/29680264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2018.04.016
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