Quality Control of Therapeutic Peptides by (1)H NMR HiFSA Sequencing

Ensuring identity, purity, and reproducibility are equally essential during synthetic chemistry, drug discovery, and for pharmaceutical product safety. Many peptidic APIs are large molecules that require considerable effort for integrity assurance. This study builds on quantum mechanical (1)H iterat...

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Pubblicato in:J Org Chem
Autori principali: Choules, Mary P., Bisson, Jonathan, Gao, Wei, Lankin, David C., McAlpine, James B., Niemitz, Matthias, Jaki, Birgit U., Franzblau, Scott G., Pauli, Guido F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452441/
https://ncbi.nlm.nih.gov/pubmed/30793905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b02704
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