ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition

There is increasing evidence that genomic instability is a prerequisite for cancer progression. Here we show that SIM2s, a member of the bHLH/PAS family of transcription factors, regulates DNA damage repair through enhancement of homologous recombination, and prevents epithelial mesenchymal transiti...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Pearson, Scott J., Sarkar, Tapasree Roy, McQueen, Cole M., Elswood, Jessica, Schmitt, Emily E., Wall, Steven W., Scribner, Kelly C., Wyatt, Garhett, Barhoumi, Rola, Behbod, Fariba, Rijnkels, Monique, Porter, Weston W.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450754/
https://ncbi.nlm.nih.gov/pubmed/30531838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0622-4
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