ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition

There is increasing evidence that genomic instability is a prerequisite for cancer progression. Here we show that SIM2s, a member of the bHLH/PAS family of transcription factors, regulates DNA damage repair through enhancement of homologous recombination, and prevents epithelial mesenchymal transiti...

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Publicat a:Oncogene
Autors principals: Pearson, Scott J., Sarkar, Tapasree Roy, McQueen, Cole M., Elswood, Jessica, Schmitt, Emily E., Wall, Steven W., Scribner, Kelly C., Wyatt, Garhett, Barhoumi, Rola, Behbod, Fariba, Rijnkels, Monique, Porter, Weston W.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450754/
https://ncbi.nlm.nih.gov/pubmed/30531838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0622-4
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