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Physical basis for the loading of a bacterial replicative helicase onto DNA
In cells, dedicated AAA+ ATPases deposit hexameric, ring-shaped helicases onto DNA to initiate chromosomal replication. To better understand the mechanisms by which helicase loading can occur, we used cryo-EM to determine sub-4 Å-resolution structures of the E. coli DnaB•DnaC helicase•loader complex...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6450724/ https://ncbi.nlm.nih.gov/pubmed/30797687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.023 |
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