In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers

A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea heterodimers 18–22, and to measure interference with type I and II topoisomerases. Their biological profile was also inspec...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Janockova, Jana, Korabecny, Jan, Plsikova, Jana, Babkova, Katerina, Konkolova, Eva, Kucerova, Dana, Vargova, Jana, Koval, Jan, Jendzelovsky, Rastislav, Fedorocko, Peter, Kasparkova, Jana, Brabec, Viktor, Rosocha, Jan, Soukup, Ondrej, Hamulakova, Slavka, Kuca, Kamil, Kozurkova, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450562/
https://ncbi.nlm.nih.gov/pubmed/30938202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1593159
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