A novel form of 4-1BBL prevents cancer development via non-specific activation of CD4(+) T and Natural Killer cells

Costimulation through 4–1BB (CD137) receptor generates robust CD8(+) T effector and memory responses. The only known ligand, 4–1BBL, is a trimeric transmembrane protein that has no costimulatory activity as a soluble molecule. Thus, agonistic antibodies to the receptor have been used for cancer immu...

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Publicado no:Cancer Res
Main Authors: Barsoumian, Hampartsoum B., Batra, Lalit, Shrestha, Pradeep, Bowen, William S., Zhao, Hong, Egilmez, Nejat K., Gomez-Gutierrez, Jorge G., Yolcu, Esma S., Shirwan, Haval
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450554/
https://ncbi.nlm.nih.gov/pubmed/30770367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2401
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