Učitavanje...
A novel form of 4-1BBL prevents cancer development via non-specific activation of CD4(+) T and Natural Killer cells
Costimulation through 4–1BB (CD137) receptor generates robust CD8(+) T effector and memory responses. The only known ligand, 4–1BBL, is a trimeric transmembrane protein that has no costimulatory activity as a soluble molecule. Thus, agonistic antibodies to the receptor have been used for cancer immu...
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| Izdano u: | Cancer Res |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6450554/ https://ncbi.nlm.nih.gov/pubmed/30770367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2401 |
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