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4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4(+)CD25(+)FoxP3(+) T Regulatory Cell Suppression
Costimulation with the recombinant SA-4-1BBL agonist of 4-1BB receptor on conventional CD4(+) T cells (Tconvs) overcomes the suppression mediated by naturally occurring CD4(+)CD25(+)FoxP3(+) T regulatory cells (Tregs). The mechanistic basis of this observation has remained largely unknown. Herein we...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4822835/ https://ncbi.nlm.nih.gov/pubmed/27049955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153088 |
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