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Copper-free dual labeling of DNA by triazines and cyclopropenes as minimal orthogonal and bioorthogonal functions

Two different and small functions for inverse electron demand Diels–Alder reactions were applied for dual labeling of DNA: the 1,2,4-triazine was attached to the 5-position of 2′-deoxyuridine triphosphate, and the 1-methylcyclopropene to the 7-position of 7-deaza-2′-deoxyadenosine triphosphate. Thes...

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Publicat a:Chem Sci
Autors principals: Reisacher, Ulrike, Ploschik, Damian, Rönicke, Franziska, Cserép, Gergely B., Kele, Péter, Wagenknecht, Hans-Achim
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450502/
https://ncbi.nlm.nih.gov/pubmed/31015943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05588b
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