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Deciphering the role of trehalose in hindering antithrombin polymerization

Serine protease inhibitors (serpins) family have a complex mechanism of inhibition that requires a large scale conformational change. Antithrombin (AT), a member of serpin superfamily serves as a key regulator of the blood coagulation cascade, deficiency of which leads to thrombosis. In recent years...

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Podrobná bibliografie
Vydáno v:Biosci Rep
Hlavní autoři: Naseem, Asma, Khan, Mohammad Sazzad, Ali, Hashim, Ahmad, Irshad, Jairajpuri, Mohamad Aman
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449516/
https://ncbi.nlm.nih.gov/pubmed/30886063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20182259
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