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Time-resolved multirotational dynamics of single solution-phase tau proteins reveals details of conformational variation
Intrinsically disordered proteins (IDPs) are crucial to many cellular processes and have been linked to neurodegenerative diseases. Single molecules of tau, an IDP associated with Alzheimer’s disease, are trapped in solution using a microfluidic device, and a time-resolved fluorescence anisotropy de...
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| Udgivet i: | Phys Chem Chem Phys |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6449148/ https://ncbi.nlm.nih.gov/pubmed/30632561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cp06971a |
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