Revealing Conformational Variants of Solution-Phase Intrinsically Disordered Tau Protein at the Single-Molecule Level

Intrinsically disordered proteins, such as tau protein, adopt a variety of conformations in solution, complicating solution-phase structural studies. We employ an anti-Brownian electrokinetic (ABEL) trap to prolong measurements of single tau proteins in solution. Once trapped, we record the fluoresc...

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Bibliografiska uppgifter
I publikationen:Angew Chem Int Ed Engl
Huvudupphovsmän: Manger, Lydia H., Foote, Alexander K., Wood, Sharla L., Holden, Michael R., Heylman, Kevin D., Margittai, Martin, Goldsmith, Randall H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831721/
https://ncbi.nlm.nih.gov/pubmed/29063723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201708242
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