Mixed-Effects Association of Single Cells Identifies an Expanded Effector CD4+ T Cell Subset in Rheumatoid Arthritis

High dimensional single-cell analyses have improved the ability to resolve complex mixtures of cells from human disease samples; however, identifying disease-associated cell types or cell states in patient samples remains challenging due to technical and inter-individual variation. Here we present M...

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Publicat a:Sci Transl Med
Autors principals: Fonseka, Chamith Y., Rao, Deepak A., Teslovich, Nikola C., Korsunsky, Ilya, Hannes, Susan K., Slowikowsi, Kamil, Gurish, Michael F., Donlin, Laura T., Lederer, James A., Weinblatt, Michael E., Massarotti, Elena M., Coblyn, Jonathan S., Helfgott, Simon M., Todd, Derrick J., Bykerk, Vivian P., Karlson, Elizabeth W., Ermann, Joerg, Lee, Yvonne C., Brenner, Michael B., Raychaudhuri, Soumya
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448773/
https://ncbi.nlm.nih.gov/pubmed/30333237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaq0305
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