Mixed-Effects Association of Single Cells Identifies an Expanded Effector CD4+ T Cell Subset in Rheumatoid Arthritis

High dimensional single-cell analyses have improved the ability to resolve complex mixtures of cells from human disease samples; however, identifying disease-associated cell types or cell states in patient samples remains challenging due to technical and inter-individual variation. Here we present M...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Fonseka, Chamith Y., Rao, Deepak A., Teslovich, Nikola C., Korsunsky, Ilya, Hannes, Susan K., Slowikowsi, Kamil, Gurish, Michael F., Donlin, Laura T., Lederer, James A., Weinblatt, Michael E., Massarotti, Elena M., Coblyn, Jonathan S., Helfgott, Simon M., Todd, Derrick J., Bykerk, Vivian P., Karlson, Elizabeth W., Ermann, Joerg, Lee, Yvonne C., Brenner, Michael B., Raychaudhuri, Soumya
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448773/
https://ncbi.nlm.nih.gov/pubmed/30333237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaq0305
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