Targeting sphingosine kinase 2 suppresses cell growth and synergizes with BCL2/BCL-XL inhibitors through NOXA-mediated MCL1 degradation in cholangiocarcinoma

Sphingosine kinase 2 (SPHK2) is a key factor within sphingolipid metabolism, responsible for the conversion of pro-apoptotic sphingosine to the pro-survival sphingosine-1-phosphate. We have previously shown that ABC294640, a first-in-class SPHK2 inhibitor, inhibits growth of cholangiocarcinoma cells...

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Vydáno v:Am J Cancer Res
Hlavní autoři: Ding, Xiwei, Zhang, Yiyang, Huang, Tianlu, Xu, Guifang, Peng, Chunyan, Chen, Gang, Kong, Bo, Friess, Helmut, Shen, Shanshan, Lv, Ying, Roberts, Lewis R, Wang, Lei, Zou, Xiaoping
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448062/
https://ncbi.nlm.nih.gov/pubmed/30949409
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