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Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein–Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with Δ(9)-Tetrahydrocannabinol and JWH-018
Most cannabinoid 1 receptor (CB(1)R) agonists will signal through both G protein–dependent and –independent pathways in an unbiased manner. Recruitment of β-arrestin 2 desensitizes and internalizes receptors, producing tolerance that limits therapeutic utility of cannabinoids for chronic conditions....
Kaydedildi:
| Yayımlandı: | J Pharmacol Exp Ther |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6447997/ https://ncbi.nlm.nih.gov/pubmed/30833484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.252965 |
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