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The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based Inhibitors

Epoxide hydrolases (EHs) are enzymes involved in the metabolism of endogenous and exogenous epoxides, and the development of EH inhibitors has important applications in the medicine. In humans, EH inhibitors are being tested in the treatment of cardiovascular diseases and show potent anti-inflammato...

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Bibliographic Details
Published in:Int J Biol Macromol
Main Authors: de Oliveira, Gabriel S., Adriani, Patricia P., Ribeiro, João Augusto, Morisseau, Christophe, Hammock, Bruce D., Dias, Marcio Vinicius B., Chambergo, Felipe S.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447457/
https://ncbi.nlm.nih.gov/pubmed/30771398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijbiomac.2019.02.070
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