The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3’UTRs of mRNAs that are directed for NMD in the cytoplasm. Here we offer evidence, obtained from Drosophila, that UPF1 constantly moves between...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Singh, Anand K, Choudhury, Subhendu Roy, De, Sandip, Zhang, Jie, Kissane, Stephen, Dwivedi, Vibha, Ramanathan, Preethi, Petric, Marija, Orsini, Luisa, Hebenstreit, Daniel, Brogna, Saverio
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447362/
https://ncbi.nlm.nih.gov/pubmed/30907728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41444
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