The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3’UTRs of mRNAs that are directed for NMD in the cytoplasm. Here we offer evidence, obtained from Drosophila, that UPF1 constantly moves between...

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Udgivet i:eLife
Main Authors: Singh, Anand K, Choudhury, Subhendu Roy, De, Sandip, Zhang, Jie, Kissane, Stephen, Dwivedi, Vibha, Ramanathan, Preethi, Petric, Marija, Orsini, Luisa, Hebenstreit, Daniel, Brogna, Saverio
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Chromosomes and Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447362/
https://ncbi.nlm.nih.gov/pubmed/30907728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41444
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