Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.
Nonsense-mediated mRNA decay, the accelerated turnover of mRNAs transcribed from genes containing early nonsense mutations, is dependent on the product of the UPF1 gene in yeast. Mutations that inactivate UPF1 lead to the selective stabilization of mRNAs containing early nonsense mutations but have...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8346213/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.15.7034 |
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