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Targeting Sphingosine Kinases for the Treatment of Cancer
Sphingosine kinases (SK1 and SK2) are key, druggable targets within the sphingolipid metabolism pathway that promote tumor growth and pathologic inflammation. A variety of isozyme-selective and dual inhibitors of SK1 and SK2 have been described in the literature, and at least one compound has reache...
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| Publicado no: | Adv Cancer Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6447312/ https://ncbi.nlm.nih.gov/pubmed/30060814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.acr.2018.04.015 |
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