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A Semi-Synthesis of an Anticancer DPAGT1 Inhibitor from a Muraymycin Biosynthetic Intermediate
We have explored a method to convert a muraymycin biosynthetic intermediate 3 to an anticancer drug lead 2 for in vivo and thorough preclinical studies. Cu(OAc)(2) forms a stable complex with the amide 4 and it prevents electrophilic reactions at the 2-((3-aminopropyl)amino)acetamide moiety. Under t...
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| Publicado no: | Org Lett |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6447083/ https://ncbi.nlm.nih.gov/pubmed/30698984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b03716 |
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