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Stereocontrolled Total Synthesis of Muraymycin D1 Having a Dual Mode of Action against Mycobacterium tuberculosis
A stereocontrolled first total synthesis of muraymycin D1 (1) has been achieved. The synthetic route is highly stereoselective, featuring 1) selective β-ribosylation of the C2-methylated amino ribose, 2) selective Strecker reaction, 3) ring-opening reaction of a diastereomeric mixture of a diaminola...
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| Publicat a: | J Am Chem Soc |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5053896/ https://ncbi.nlm.nih.gov/pubmed/27617631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07395 |
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