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Stereocontrolled Total Synthesis of Muraymycin D1 Having a Dual Mode of Action against Mycobacterium tuberculosis

A stereocontrolled first total synthesis of muraymycin D1 (1) has been achieved. The synthetic route is highly stereoselective, featuring 1) selective β-ribosylation of the C2-methylated amino ribose, 2) selective Strecker reaction, 3) ring-opening reaction of a diastereomeric mixture of a diaminola...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Mitachi, Katsuhiko, Aleiwi, Bilal A., Schneider, Christopher M., Siricilla, Shajila, Kurosu, Michio
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053896/
https://ncbi.nlm.nih.gov/pubmed/27617631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07395
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