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Mild and convenient N-formylation protocol in water-containing solvents

We have realized that N-formylations of free amines of some drug leads can improve PK/PD property of parent molecules without decreasing their biological activities. In order to selectively formylate primary amines of polyfunctional molecules, we have sought a mild and convenient formylation reactio...

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Bibliographic Details
Main Authors: Aleiwi, Bilal A., Mitachi, Katsuhiko, Kurosu, Michio
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727664/
https://ncbi.nlm.nih.gov/pubmed/23908559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2013.02.013
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