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Indirect Pharmacodynamic Models for Responses with Circadian Removal
Rhythmicity in baseline responses over a 24-hour period for an indirect pharmacological effect R(t) can arise from either a periodic time-dependent input rate k(in) (t) or a periodic time-dependent loss constant k(out) (t). If either k(in) (t) or k(out) (t) follows some nonstationary biological rhyt...
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| Udgivet i: | J Pharmacokinet Pharmacodyn |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6447046/ https://ncbi.nlm.nih.gov/pubmed/30694437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-019-09620-z |
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