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Synthesis, antiviral activity, and structure-activity relationship of 1,3-benzodioxolyl pyrrole-based entry inhibitors targeting the Phenyl43 cavity in HIV-1 gp120

The pathway by which HIV-1 enters host cells is a prime target for novel drug discovery because of its critical role in the HIV-1 life cycle. The HIV-1 envelop glycoprotein gp120 plays an important role in initiating virus entry by targeting the primary cell receptor CD4. We explored the substitutio...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:ChemMedChem
Main Authors: Curreli, Francesca, Belov, Dmitry S, Ahmed, Shahad, Ramesh, Ranjith R., Kurkin, Alexander V, Altieri, Andrea, Debnath, Asim K
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446940/
https://ncbi.nlm.nih.gov/pubmed/30257071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800534
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