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Synthesis, antiviral activity, and structure-activity relationship of 1,3-benzodioxolyl pyrrole-based entry inhibitors targeting the Phenyl43 cavity in HIV-1 gp120
The pathway by which HIV-1 enters host cells is a prime target for novel drug discovery because of its critical role in the HIV-1 life cycle. The HIV-1 envelop glycoprotein gp120 plays an important role in initiating virus entry by targeting the primary cell receptor CD4. We explored the substitutio...
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| Publicado no: | ChemMedChem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6446940/ https://ncbi.nlm.nih.gov/pubmed/30257071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800534 |
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