Chronic oral rapamycin decreases adiposity, hepatic triglycerides, and insulin resistance in male mice fed a diet high in sucrose and saturated fat

AIMS/HYPOTHESIS: Excess adiposity is commonly associated with insulin resistance, which can increase the risk of cardiovascular disease. However, the exact molecular mechanisms by which obesity results in insulin resistance are yet to be clearly understood. The intracellular nutrient sensing protein...

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Bibliographic Details
Published in:Exp Physiol
Main Authors: den Hartigh, Laura J, Goodspeed, Leela, Wang, Shari A, Kenerson, Heidi L., Omer, Mohamed, O’Brien, Kevin D., Ladiges, Warren, Yeung, Raymond, Subramanian, Savitha
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446929/
https://ncbi.nlm.nih.gov/pubmed/30117227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/EP087207
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