CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization

Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase PP2A-B55 regulate the engagement of human MPS1 with unattached kinetochores by controlling the phosphorylation status of S281...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Hayward, Daniel, Alfonso-Pérez, Tatiana, Cundell, Michael J., Hopkins, Michael, Holder, James, Bancroft, James, Hutter, Lukas H., Novak, Bela, Barr, Francis A., Gruneberg, Ulrike
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446832/
https://ncbi.nlm.nih.gov/pubmed/30674582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201808014
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