Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells

In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also indicates that lysosome secretion can be cont...

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Vydáno v:J Lipid Res
Hlavní autoři: Vacca, Fabrizio, Vossio, Stefania, Mercier, Vincent, Moreau, Dimitri, Johnson, Shem, Scott, Cameron C., Montoya, Jonathan Paz, Moniatte, Marc, Gruenberg, Jean
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446697/
https://ncbi.nlm.nih.gov/pubmed/30709900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M089979
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