Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells

BACKGROUND: Most tumor cells show aberrantly activated Akt which leads to increased cell survival and resistance to cancer radiotherapy. Therefore, targeting Akt can be a promising strategy for radiosensitization. Here, we explore the impact of the Akt inhibitor MK-2206 alone and in combination with...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Djuzenova, Cholpon S., Fiedler, Vanessa, Memmel, Simon, Katzer, Astrid, Sisario, Dmitri, Brosch, Philippa K., Göhrung, Alexander, Frister, Svenja, Zimmermann, Heiko, Flentje, Michael, Sukhorukov, Vladimir L.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446411/
https://ncbi.nlm.nih.gov/pubmed/30943918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5517-4
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